MODULE 2: Epilepsy Medication Therapy 4 Epilepsy Medications How Do Epilepsy Medications Work? Epilepsy medications work by changing the way neurons (nerve cells) in the brain talk to each other. AEDs decrease neuron overactivity in the brain. Fewer overactive neurons may lead to fewer seizures.2 Overactive electrical signals in the neurons of the brain2 AEDs decrease the overactive electrical signals in the neurons of the brain2